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2017 ; 7
(7
): 1795-1805
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Current and emerging techniques for antibiotic susceptibility tests
#MMPMID28638468
Syal K
; Mo M
; Yu H
; Iriya R
; Jing W
; Guodong S
; Wang S
; Grys TE
; Haydel SE
; Tao N
Theranostics
2017[]; 7
(7
): 1795-1805
PMID28638468
show ga
Infectious diseases caused by bacterial pathogens are a worldwide burden. Serious
bacterial infection-related complications, such as sepsis, affect over a million
people every year with mortality rates ranging from 30% to 50%. Crucial clinical
microbiology laboratory responsibilities associated with patient management and
treatment include isolating and identifying the causative bacterium and
performing antibiotic susceptibility tests (ASTs), which are labor-intensive,
complex, imprecise, and slow (taking days, depending on the growth rate of the
pathogen). Considering the life-threatening condition of a septic patient and the
increasing prevalence of antibiotic-resistant bacteria in hospitals, rapid and
automated diagnostic tools are needed. This review summarizes the existing
commercial AST methods and discusses some of the promising emerging AST tools
that will empower humans to win the evolutionary war between microbial genes and
human wits.