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10.1016/j.mocell.2025.100274 http://scihub22266oqcxt.onion/10.1016/j.mocell.2025.100274 40914459!ä!40914459 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\40914459.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cells 2025 ; ä (ä): 100274 Nephropedia Template TP {{tp|p=40914459|t=2025. Current Therapeutic Strategies in Parkinson s Disease: Future Perspectives |pdf=|usr=}}{{40914459}} gab.com Text Current Therapeutic Strategies in Parkinson s Disease: Future Perspectives JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=40914459 #FOAvip Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded alpha-synuclein. Current treatments, including dopaminergic medications and deep brain stimulation (DBS), provide symptomatic relief but do not halt disease progression. Recent advances in molecular research have enabled the development of disease-modifying strategies targeting key pathogenic mechanisms, such as alpha-synuclein aggregation, mitochondrial dysfunction, and genetic mutations including LRRK2 and GBA1. In parallel, pluripotent stem cell (PSC)-derived dopaminergic neurons have emerged as a scalable and ethically viable source for cell replacement therapy. Early-phase clinical trials have demonstrated the safety and functional integration of these grafts. Ongoing research is now focused on enhancing graft purity, immune compatibility, and anatomical precision, including homotopic transplantation and circuit-level reconstruction. Together, these emerging strategies offer the potential to shift PD treatment paradigms by combining symptomatic control with long-term neural restoration. This review summarizes current therapeutic approaches and highlights recent advances in disease-modifying and regenerative interventions for PD. Twit Text FOAVip Current Therapeutic Strategies in Parkinson s Disease: Future Perspectives ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=40914459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=40914459 #FOAvip English Wikipedia <ref>{{Cite pmid|40914459}}</ref> Current Therapeutic Strategies in Parkinson s Disease: Future Perspectives #MMPMID40914459 Kim TY; Lee BD Mol Cells 2025[Sep]; ä (ä): 100274 PMID40914459show ga Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded alpha-synuclein. Current treatments, including dopaminergic medications and deep brain stimulation (DBS), provide symptomatic relief but do not halt disease progression. Recent advances in molecular research have enabled the development of disease-modifying strategies targeting key pathogenic mechanisms, such as alpha-synuclein aggregation, mitochondrial dysfunction, and genetic mutations including LRRK2 and GBA1. In parallel, pluripotent stem cell (PSC)-derived dopaminergic neurons have emerged as a scalable and ethically viable source for cell replacement therapy. Early-phase clinical trials have demonstrated the safety and functional integration of these grafts. Ongoing research is now focused on enhancing graft purity, immune compatibility, and anatomical precision, including homotopic transplantation and circuit-level reconstruction. Together, these emerging strategies offer the potential to shift PD treatment paradigms by combining symptomatic control with long-term neural restoration. This review summarizes current therapeutic approaches and highlights recent advances in disease-modifying and regenerative interventions for PD. äCurrent Therapeutic Strategies in Parkinson s Disease: Future Perspect(epmc).pdf DeepDyve Pubget Overpricing