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2018 ; 6
(2
): ä Nephropedia Template TP
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English Wikipedia
Current Strategies to Enhance Anti-Tumour Immunity
#MMPMID29570634
Cook KW
; Durrant LG
; Brentville VA
Biomedicines
2018[Mar]; 6
(2
): ä PMID29570634
show ga
The interaction of the immune system with cancer is complex, but new approaches
are resulting in exciting therapeutic benefits. In order to enhance the immune
response to cancer, immune therapies seek to either induce high avidity immune
responses to tumour specific antigens or to convert the tumour to a more
pro-inflammatory microenvironment. Strategies, including vaccination, oncolytic
viruses, and adoptive cell transfer all seek to induce anti-tumour immunity. To
overcome the suppressive tumour microenvironment checkpoint inhibitors and
modulators of regulatory cell populations have been investigated. This review
summarizes the recent advances in immune therapies and discusses the importance
of combination therapies in the treatment of cancers.