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2015 ; 5
(2
): 1239-63
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Current Ideas about Prebiological Compartmentalization
#MMPMID25867709
Monnard PA
; Walde P
Life (Basel)
2015[Apr]; 5
(2
): 1239-63
PMID25867709
show ga
Contemporary biological cells are highly sophisticated dynamic compartment
systems which separate an internal volume from the external medium through a
boundary, which controls, in complex ways, the exchange of matter and energy
between the cell's interior and the environment. Since such compartmentalization
is a fundamental principle of all forms of life, scenarios have been elaborated
about the emergence of prebiological compartments on early Earth, in particular
about their likely structural characteristics and dynamic features. Chemical
systems that consist of potentially prebiological compartments and chemical
reaction networks have been designed to model pre-cellular systems. These systems
are often referred to as "protocells". Past and current protocell model systems
are presented and compared. Since the prebiotic formation of cell-like
compartments is directly linked to the prebiotic availability of compartment
building blocks, a few aspects on the likely chemical inventory on the early
Earth are also summarized.