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10.3389/fimmu.2018.01643 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.01643 C6054923!6054923 !30061897     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30061897 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2018 ; 9 (ä): 1643 Nephropedia Template TP {{tp|p=30061897 |t=2018. Current Concepts of Antigen Cross-Presentation |pdf=|usr=}}{{30061897 }} gab.com Text Current Concepts of Antigen Cross-Presentation JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30061897 #FOAvip Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance. The molecular mechanisms enabling cross-presentation have been topic of intense debate since many years. However, a clear view on these mechanisms remains difficult, partially due to important remaining questions, controversial results and discussions. Here, we give an overview of the current concepts of antigen cross-presentation and focus on a description of the major cross-presentation pathways, the role of retarded antigen degradation for efficient cross-presentation, the dislocation of antigens from endosomal compartment into the cytosol, the reverse transport of proteasome-derived peptides for loading on MHC I and the translocation of the cross-presentation machinery from the ER to endosomes. We try to highlight recent advances, discuss some of the controversial data and point out some of the major open questions in the field. Twit Text FOAVip Current Concepts of Antigen Cross-Presentation ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=30061897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30061897 #FOAvip English Wikipedia <ref>{{Cite pmid|30061897 }}</ref> Current Concepts of Antigen Cross-Presentation #MMPMID30061897 Embgenbroich M ; Burgdorf S Front Immunol 2018[]; 9 (ä): 1643 PMID30061897 show ga Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance. The molecular mechanisms enabling cross-presentation have been topic of intense debate since many years. However, a clear view on these mechanisms remains difficult, partially due to important remaining questions, controversial results and discussions. Here, we give an overview of the current concepts of antigen cross-presentation and focus on a description of the major cross-presentation pathways, the role of retarded antigen degradation for efficient cross-presentation, the dislocation of antigens from endosomal compartment into the cytosol, the reverse transport of proteasome-derived peptides for loading on MHC I and the translocation of the cross-presentation machinery from the ER to endosomes. We try to highlight recent advances, discuss some of the controversial data and point out some of the major open questions in the field. äCurrent Concepts of Antigen Cross-Presentation (epmc).pdf DeepDyve Pubget Overpricing