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2015 ; 34
(3
): 271-281
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Curious Cases of the Enzymes
#MMPMID28356837
Ulusu NN
J Med Biochem
2015[Jul]; 34
(3
): 271-281
PMID28356837
show ga
Life as we know it heavily relies on biological catalysis, in fact, in a very
nonromantic version of it, life could be considered as a series of chemical
reactions, regulated by the guarding principles of thermodynamics. In ancient
times, a beating heart was a good sign of vitality, however, to me, it is
actually the presence of active enzymes that counts? Though we do not usually pay
attention, the history of enzymology is as old as humanity itself, and dates back
to the ancient times. This paper is dedicated to these early moments of this
remarkable science that touched our lives in the past and will make life a lot
more efficient for humanity in the future. There was almost always a delicate,
fundamentally essential relationship between mankind and the enzymes. Challenged
by a very alien and hostile Nature full of predators, prehistoric men soon
discovered the medicinal properties of the plants, through trial and error. In
fact, they accidently discovered the enzyme inhibitors and thus, in crude terms,
kindled a sparkling area of research. These plant-derivatives that acted as
enzyme inhibitors helped prehistoric men in their pursuit of survival and
protection from predators; in hunting and fishing? Later in history, while the
underlying purposes of survival and increasing the quality of life stayed intact,
the ways and means of enzymology experienced a massive transformation, as the
'trial and error' methodology of the ancients is now replaced with rational
scientific theories.
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