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Curcumin: from ancient medicine to current clinical trials
#MMPMID18324353
Hatcher H
; Planalp R
; Cho J
; Torti FM
; Torti SV
Cell Mol Life Sci
2008[Jun]; 65
(11
): 1631-52
PMID18324353
show ga
Curcumin is the active ingredient in the traditional herbal remedy and dietary
spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of
beneficial properties, including anti-inflammatory, antioxidant, chemopreventive
and chemotherapeutic activity. The pleiotropic activities of curcumin derive from
its complex chemistry as well as its ability to influence multiple signaling
pathways, including survival pathways such as those regulated by NF-kappaB, Akt,
and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and
angiogenic pathways. Curcumin is a free radical scavenger and hydrogen donor, and
exhibits both pro- and antioxidant activity. It also binds metals, particularly
iron and copper, and can function as an iron chelator. Curcumin is remarkably
non-toxic and exhibits limited bioavailability. Curcumin exhibits great promise
as a therapeutic agent, and is currently in human clinical trials for a variety
of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic
syndromes, colon cancer, psoriasis and Alzheimer's disease.
|*Anti-Inflammatory Agents, Non-Steroidal/chemistry/metabolism/therapeutic use
[MESH]
|*Antineoplastic Agents/chemistry/metabolism/therapeutic use
[MESH]
|*Antioxidants/chemistry/metabolism/therapeutic use
[MESH]
|*Curcumin/chemistry/metabolism/therapeutic use
[MESH]
|*Free Radical Scavengers/chemistry/metabolism/therapeutic use
[MESH]
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