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Crosstalk signaling between alveoli and capillaries
#MMPMID29869931
Hough RF
; Bhattacharya S
; Bhattacharya J
Pulm Circ
2018[Jul]; 8
(3
): 2045894018783735
PMID29869931
show ga
Crosstalk signaling between the closely juxtaposed epithelial and endothelial
membranes of pulmonary alveoli establishes the lung's immune defense against
inhaled and blood-borne pathogens. The crosstalk can occur in a forward
direction, as from alveolus to capillary, or in a reverse direction, as from
capillary to alveolus. The crosstalk direction likely depends on the site at
which pathogens first initiate signaling. Thus, forward crosstalk may occur when
inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may
result from interactions of blood-borne pathogens with the endothelium. Here, we
review the factors that regulate these two directions of signaling.