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10.4161/21541248.2014.989789 http://scihub22266oqcxt.onion/10.4161/21541248.2014.989789 C4601376!4601376 !25942647     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25942647 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Small+GTPases 2015 ; 6 (2 ): 71-80 Nephropedia Template TP {{tp|p=25942647 |t=2015. Crossroads of PI3K and Rac pathways |pdf=|usr=}}{{25942647 }} gab.com Text Crossroads of PI3K and Rac pathways JO: Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25942647 #FOAvip Rac and PI3Ks are intracellular signal transducers able to regulate multiple signaling pathways fundamental for cell behavior. PI3Ks are lipid kinases that produce phosphorylated lipids which, in turn, transduce extracellular cues within the cell, while Rac is a small G protein that impacts on actin organization. Compelling evidence indicates that in multiple circumstances the 2 signaling pathways appear intermingled. For instance, phosphorylated lipids produced by PI3Ks recruit and activate GEF and GAP proteins, key modulators of Rac function. Conversely, PI3Ks interact with activated Rac, leading to Rac signaling amplification. This review summarizes the molecular mechanisms underlying the cross-talk between Rac and PI3K signaling in 2 different processes, cell migration and ROS production. Twit Text FOAVip Crossroads of PI3K and Rac pathways ????Small GTPases http://www.kidney.de/pget.php?&tw=1&pmid=25942647 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25942647 #FOAvip English Wikipedia <ref>{{Cite pmid|25942647 }}</ref> Crossroads of PI3K and Rac pathways #MMPMID25942647 Campa CC ; Ciraolo E ; Ghigo A ; Germena G ; Hirsch E Small GTPases 2015[]; 6 (2 ): 71-80 PMID25942647 show ga Rac and PI3Ks are intracellular signal transducers able to regulate multiple signaling pathways fundamental for cell behavior. PI3Ks are lipid kinases that produce phosphorylated lipids which, in turn, transduce extracellular cues within the cell, while Rac is a small G protein that impacts on actin organization. Compelling evidence indicates that in multiple circumstances the 2 signaling pathways appear intermingled. For instance, phosphorylated lipids produced by PI3Ks recruit and activate GEF and GAP proteins, key modulators of Rac function. Conversely, PI3Ks interact with activated Rac, leading to Rac signaling amplification. This review summarizes the molecular mechanisms underlying the cross-talk between Rac and PI3K signaling in 2 different processes, cell migration and ROS production. |*Second Messenger Systems [MESH] |Animals [MESH] |Humans [MESH] |Phosphatidylinositol 3-Kinases/chemistry/genetics/*metabolism [MESH]Crossroads of PI3K and Rac pathways (epmc).pdf DeepDyve Pubget Overpricing