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Cross-kingdom interactions: Candida albicans and bacteria
#MMPMID19552706
Shirtliff ME
; Peters BM
; Jabra-Rizk MA
FEMS Microbiol Lett
2009[Oct]; 299
(1
): 1-8
PMID19552706
show ga
Bacteria and fungi are found together in a myriad of environments and
particularly in a biofilm, where adherent species interact through diverse
signaling mechanisms. Yet, despite billions of years of coexistence, the area of
research exploring fungal-bacterial interactions, particularly within the context
of polymicrobial infections, is still in its infancy. However, reports describing
a multitude of wide-ranging interactions between the fungal pathogen Candida
albicans and various bacterial pathogens are on the rise. An example of a
mutually beneficial interaction is coaggregation, a phenomenon that takes place
in oral biofilms where the adhesion of C. albicans to oral bacteria is considered
crucial for its colonization of the oral cavity. In contrast, the interaction
between C. albicans and Pseudomonas aeruginosa is described as being competitive
and antagonistic in nature. Another intriguing interaction is that occurring
between Staphylococcus aureus and C. albicans, which although not yet fully
characterized, appears to be initially synergistic. These complex interactions
between such diverse and important pathogens would have significant clinical
implications if they occurred in an immunocompromised host. Therefore,
understanding the mechanisms of adhesion and signaling involved in
fungal-bacterial interactions may lead to the development of novel therapeutic
strategies for impeding microbial colonization and development of polymicrobial
disease.
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