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2014 ; 10
(4
): 556-61
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Cracking the survival code: autophagy-related histone modifications
#MMPMID24429873
Füllgrabe J
; Heldring N
; Hermanson O
; Joseph B
Autophagy
2014[Apr]; 10
(4
): 556-61
PMID24429873
show ga
Modifications of histones, the chief protein components of the chromatin, have
emerged as critical regulators of life and death. While the "apoptotic histone
code" came to light a few years ago, accumulating evidence indicates that
autophagy, a cell survival pathway, is also heavily regulated by
histone-modifying proteins. In this review we describe the emerging "autophagic
histone code" and the role of histone modifications in the cellular life vs.
death decision.