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2020 ; 51
(6
): 473-481
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Covid-19 Pandemic and Current Medical Interventions
#MMPMID32499154
Manhas S
; Anjali A
; Mansoor S
; Sharma V
; Ahmad A
; Rehman MU
; Ahmad P
Arch Med Res
2020[Aug]; 51
(6
): 473-481
PMID32499154
show ga
First humanoid coronavirus was discovered in the middle of 1960s, the class of
viruses are considered to be a huge threat. The first onset of human coronavirus,
SARS (SARS-CoV) appeared in 2003 which spanned five continents having lethal
effects on human population accompanied by The Middle East Respiratory Syndrome
Coronavirus in 2012 with a death rate of 35%. The viruses remain a threat till
date and are of serious concern since no vaccine or specified drug therapy has
been approbated for treating human coronaviruses. The viruses became a pandemic
worldwide with the emergence of Wuhan coronavirus (2019-nCoV). SARS-CoV2 viral
manifestation poses a serious human life risk by causing acute lung injury and
various respiratory outcomes and has become a global concern. High pathogenicity
and transmission rate of the viral strain has become the spotlight of research
community throughout the world. With the ongoing studies on viral structure and
host interactions, the intricacy of the viral proteome structure and replication
cycle proposes a need to explore our understanding of host factors playing role
in viral multiplication cycle. This review provides insight into our prevalent
perception of coronavirus-host interactions, structure of SARS-CoV2, receptor
mediated entry of virus inside the human cells, ongoing clinical trials, drug
therapies and treatments that are being used to combat COVID-19 targeting viral
fusion, replication and its multiplication.
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