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10.1100/tsw.2002.105

http://scihub22266oqcxt.onion/10.1100/tsw.2002.105
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C6009572!6009572 !12806028
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suck abstract from ncbi


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pmid12806028
      ScientificWorldJournal 2002 ; 2 (ä): 434-54
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  • Coupling planar cell polarity signaling to morphogenesis #MMPMID12806028
  • Axelrod JD ; McNeill H
  • ScientificWorldJournal 2002[Feb]; 2 (ä): 434-54 PMID12806028 show ga
  • Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.
  • |*Zebrafish Proteins [MESH]
  • |Animals [MESH]
  • |Cell Polarity/genetics/*physiology [MESH]
  • |Cytoskeleton/physiology [MESH]
  • |Drosophila Proteins/genetics/physiology [MESH]
  • |Drosophila/cytology/genetics/growth & development [MESH]
  • |Frizzled Receptors [MESH]
  • |Gene Expression Regulation, Developmental [MESH]
  • |Membrane Proteins/genetics/physiology [MESH]
  • |Models, Biological [MESH]
  • |Morphogenesis/genetics/*physiology [MESH]
  • |Mutation [MESH]
  • |Proto-Oncogene Proteins/genetics/physiology [MESH]
  • |Receptors, G-Protein-Coupled [MESH]
  • |Signal Transduction/genetics/*physiology [MESH]


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