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2002 ; 2
(ä): 434-54
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Coupling planar cell polarity signaling to morphogenesis
#MMPMID12806028
Axelrod JD
; McNeill H
ScientificWorldJournal
2002[Feb]; 2
(ä): 434-54
PMID12806028
show ga
Epithelial cells and other groups of cells acquire a polarity orthogonal to their
apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by
which these cells become polarized requires a signaling pathway using Frizzled as
a receptor. Responding cells sense cues from their environment that provide
directional information, and they translate this information into cellular
asymmetry. Most of what is known about PCP derives from studies in the fruit fly,
Drosophila. We review what is known about how cells translate an unknown signal
into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate
processes of convergent extension and cochlear hair-cell development may relate
to Drosophila PCP signaling.
|*Zebrafish Proteins
[MESH]
|Animals
[MESH]
|Cell Polarity/genetics/*physiology
[MESH]
|Cytoskeleton/physiology
[MESH]
|Drosophila Proteins/genetics/physiology
[MESH]
|Drosophila/cytology/genetics/growth & development
[MESH]