Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28034959
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nucleic+Acids+Res
2017 ; 45
(4
): 1596-1605
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Counting the ions surrounding nucleic acids
#MMPMID28034959
Jacobson DR
; Saleh OA
Nucleic Acids Res
2017[Feb]; 45
(4
): 1596-1605
PMID28034959
show ga
Nucleic acids are strongly negatively charged, and thus electrostatic
interactions-screened by ions in solution-play an important role in governing
their ability to fold and participate in biomolecular interactions. The negative
charge creates a region, known as the ion atmosphere, in which cation and anion
concentrations are perturbed from their bulk values. Ion counting experiments
quantify the ion atmosphere by measuring the preferential ion interaction
coefficient: the net total number of excess ions above, or below, the number
expected due to the bulk concentration. The results of such studies provide
important constraints on theories, which typically predict the full
three-dimensional distribution of the screening cloud. This article reviews the
state of nucleic acid ion counting measurements and critically analyzes their
ability to test both analytical and simulation-based models.