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2015 ; 45
(9
): 1439-46
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Cough during infancy and subsequent childhood asthma
#MMPMID26011047
Oren E
; Rothers J
; Stern DA
; Morgan WJ
; Halonen M
; Wright AL
Clin Exp Allergy
2015[Sep]; 45
(9
): 1439-46
PMID26011047
show ga
OBJECTIVES: Wheezing in infancy has been associated with subsequent asthma, but
whether cough similarly influences asthma risk has been little studied. We sought
to determine whether prolonged cough and cough without cold in the first year of
life are associated with childhood asthma. METHODS: Participants in the Infant
Immune Study, a non-selected birth cohort, were surveyed 7 times in the first 9
months of life regarding the presence of wheeze and cough. Cough for more than 28
days was defined as prolonged. Parents were asked at 1 year if the child ever
coughed without a cold. Asthma was defined as parental report of physician
diagnosis of asthma, with symptoms or medication use between 2 and 9 years.
Logistic regression was used to assess adjusted odds for asthma associated with
cough characteristics. RESULTS: A total of 24% (97) of children experienced
prolonged cough and 23% (95) cough without cold in the first 9 months,
respectively. Prolonged cough was associated with increased risk of asthma
relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being
particularly high among children of asthmatic mothers. Cough without cold (OR
3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of
childhood asthma. Both relations persisted after adjustment for wheeze and total
IgE at age 1. CONCLUSIONS AND CLINICAL RELEVANCE: Prolonged cough in infancy and
cough without cold are associated with childhood asthma, independent of infant
wheeze. These findings suggest that characteristics of cough in infancy are early
markers of asthma susceptibility, particularly among children with maternal
asthma.