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2016 ; 18
(1
): 7-21
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Corticostriatal circuitry
#MMPMID27069376
Haber SN
Dialogues Clin Neurosci
2016[Mar]; 18
(1
): 7-21
PMID27069376
show ga
Corticostriatal connections play a central role in developing appropriate
goal-directed behaviors, including the motivation and cognition to develop
appropriate actions to obtain a specific outcome. The cortex projects to the
striatum topographically. Thus, different regions of the striatum have been
associated with these different functions: the ventral striatum with reward; the
caudate nucleus with cognition; and the putamen with motor control. However,
corticostriatal connections are more complex, and interactions between functional
territories are extensive. These interactions occur in specific regions in which
convergence of terminal fields from different functional cortical regions are
found. This article provides an overview of the connections of the cortex to the
striatum and their role in integrating information across reward, cognitive, and
motor functions. Emphasis is placed on the interface between functional domains
within the striatum.