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10.1007/s00775-016-1342-2 http://scihub22266oqcxt.onion/10.1007/s00775-016-1342-2 C4850187!4850187 !26883683     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26883683 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26883683 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Inorg+Chem 2016 ; 21 (3 ): 329-38 Nephropedia Template TP {{tp|p=26883683 |t=2016. Copper(II) binding properties of hepcidin |pdf=|usr=}}{{26883683 }} gab.com Text Copper(II) binding properties of hepcidin JO: J Biol Inorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=26883683 #FOAvip Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-terminal domain of hepcidin is conserved amongst a range of species and is capable of binding Cu(II) and Ni(II) through the amino terminal copper-nickel binding motif (ATCUN). It has been suggested that the binding of copper to hepcidin may have biological relevance. In this study we have investigated the binding of Cu(II) with model peptides containing the ATCUN motif, fluorescently labelled hepcidin and hepcidin using MALDI-TOF mass spectrometry. As with albumin, it was found that tetrapeptide models of hepcidin possessed a higher affinity for Cu(II) than that of native hepcidin. The log K 1 value of hepcidin for Cu(II) was determined as 7.7. Cu(II) binds to albumin more tightly than hepcidin (log K 1 = 12) and in view of the serum concentration difference of albumin and hepcidin, the bulk of kinetically labile Cu(II) present in blood will be bound to albumin. It is estimated that the concentration of Cu(II)-hepcidin will be less than one femtomolar in normal serum and thus the binding of copper to hepcidin is unlikely to play a role in iron homeostasis. As with albumin, small tri and tetra peptides are poor models for the metal binding properties of hepcidin. Twit Text FOAVip Copper(II) binding properties of hepcidin ????J Biol Inorg Chem http://www.kidney.de/pget.php?&tw=1&pmid=26883683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26883683 #FOAvip English Wikipedia <ref>{{Cite pmid|26883683 }}</ref> Copper(II) binding properties of hepcidin #MMPMID26883683 Kulprachakarn K ; Chen YL ; Kong X ; Arno MC ; Hider RC ; Srichairatanakool S ; Bansal SS J Biol Inorg Chem 2016[Jun]; 21 (3 ): 329-38 PMID26883683 show ga Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-terminal domain of hepcidin is conserved amongst a range of species and is capable of binding Cu(II) and Ni(II) through the amino terminal copper-nickel binding motif (ATCUN). It has been suggested that the binding of copper to hepcidin may have biological relevance. In this study we have investigated the binding of Cu(II) with model peptides containing the ATCUN motif, fluorescently labelled hepcidin and hepcidin using MALDI-TOF mass spectrometry. As with albumin, it was found that tetrapeptide models of hepcidin possessed a higher affinity for Cu(II) than that of native hepcidin. The log K 1 value of hepcidin for Cu(II) was determined as 7.7. Cu(II) binds to albumin more tightly than hepcidin (log K 1 = 12) and in view of the serum concentration difference of albumin and hepcidin, the bulk of kinetically labile Cu(II) present in blood will be bound to albumin. It is estimated that the concentration of Cu(II)-hepcidin will be less than one femtomolar in normal serum and thus the binding of copper to hepcidin is unlikely to play a role in iron homeostasis. As with albumin, small tri and tetra peptides are poor models for the metal binding properties of hepcidin. |Copper/*chemistry [MESH] |Hepcidins/chemical synthesis/chemistry [MESH] |Mass Spectrometry [MESH]Copper(II) binding properties of hepcidin (epmc).pdf DeepDyve Pubget Overpricing