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2015 ; 56
(4
): 976-80
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Copeptin in Hemodialysis Patients with Left Ventricular Dysfunction
#MMPMID26069119
Kim JS
; Yang JW
; Chai MH
; Lee JY
; Park H
; Kim Y
; Choi SO
; Han BG
Yonsei Med J
2015[Jul]; 56
(4
): 976-80
PMID26069119
show ga
PURPOSE: Copeptin has been considered as a useful marker for diagnosis and
prediction of prognosis in heart diseases. However, copeptin has not been
investigated sufficiently in hemodialysis patients. This study aimed to
investigate the general features of copeptin in hemodialysis and to examine the
usefulness of copeptin in hemodialysis patients with left ventricular dysfunction
(LV dysfunction). MATERIALS AND METHODS: This study included 41 patients on
regular hemodialysis. Routine laboratory data and peptides such as the N-terminal
of the prohormone brain natriuretic peptide and copeptin were measured on the day
of hemodialysis. Body fluid volume was estimated by bioimpedance spectroscopy,
and the E/Ea ratio was estimated by echocardiography. RESULTS: Copeptin increased
to 171.4 pg/mL before hemodialysis. The copeptin had a positive correlation with
pre-dialysis body fluid volume (r=0.314; p=0.04). The copeptin level decreased
along with body fluid volume and plasma osmolality during hemodialysis. The
copeptin increased in the patients with LV dysfunction more than in those with
normal LV function (218.7 pg/mL vs. 77.6 pg/mL; p=0.01). Receiver operating
characteristic curve analysis showed that copeptin had a diagnostic value in the
hemodialysis patients with LV dysfunction (area under curve 0.737; p=0.02) and
that the cut-off value was 125.48 pg/mL (sensitivity 0.7, specificity 0.8,
positive predictive value 0.9, negative predictive value 0.6). CONCLUSION:
Copeptin increases in hemodialysis patients and is higher in patients with LV
dysfunction. We believe that copeptin can be a useful marker for the diagnosis of
LV dysfunction in hemodialysis patients.