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2017 ; 2017
(ä): 7973165
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Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases
#MMPMID28326328
Brütting C
; Emmer A
; Kornhuber ME
; Staege MS
Biomed Res Int
2017[]; 2017
(ä): 7973165
PMID28326328
show ga
At least 8% of the human genome is composed of endogenous retrovirus (ERV)
sequences. ERVs play a role in placental morphogenesis and can sometimes protect
the host against exogenous viruses. On the other hand, ERV reactivation has been
found to be associated with different diseases, for example, multiple sclerosis
(MS), schizophrenia, type 1 diabetes mellitus (T1D), or amyotrophic lateral
sclerosis (ALS). Little is known about the cooccurrence of these diseases. If all
these diseases are caused by ERV, antiretroviral therapy should perhaps also show
some effects in the other diseases. Here, we summarize literature demonstrating
that some ERV-associated diseases seem to appear together more often than
expected, for example, MS and ALS, MS and T1D, MS and schizophrenia, or ALS and
T1D. In contrast, some ERV-associated diseases seem to appear together less
frequently than expected, for example, schizophrenia and T1D. Besides, some
reports demonstrate amelioration of MS, ALS, or schizophrenia under
antiretroviral therapy in human immunodeficiency virus-infected patients. If such
results could be confirmed in larger studies, alternative therapy strategies for
ERV-associated diseases like MS and schizophrenia might be possible.