Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26400439
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nat+Commun
2015 ; 6
(ä): 8299
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Convergent capture of retroviral superantigens by mammalian herpesviruses
#MMPMID26400439
Aswad A
; Katzourakis A
Nat Commun
2015[Sep]; 6
(ä): 8299
PMID26400439
show ga
Horizontal gene transfer from retroviruses to mammals is well documented and
extensive, but is rare between unrelated viruses with distinct genome types.
Three herpesviruses encode a gene with similarity to a retroviral superantigen
gene (sag) of the unrelated mouse mammary tumour virus (MMTV). We uncover ancient
retroviral sags in over 20 mammals to reconstruct their shared history with
herpesviral sags, revealing that the acquisition is a convergent evolutionary
event. A retrovirus circulating in South American primates over 10 million years
ago was the source of sag in two monkey herpesviruses, and a different retrovirus
was the source of sag in a Peruvian rodent herpesvirus. We further show through a
timescaled phylogenetic analysis that a cross-species transmission of monkey
herpesviruses occurred after the acquisition of sag. These results reveal that a
diverse range of ancient sag-containing retroviruses independently donated sag
twice from two separate lineages that are distinct from MMTV.
free
free
free
