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2015 ; 3
(1-2
): e985954
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Control of vascular permeability by adhesion molecules
#MMPMID25838987
Sarelius IH
; Glading AJ
Tissue Barriers
2015[]; 3
(1-2
): e985954
PMID25838987
show ga
Vascular permeability is a vital function of the circulatory system that is
regulated in large part by the limited flux of solutes, water, and cells through
the endothelial cell layer. One major pathway through this barrier is via the
inter-endothelial junction, which is driven by the regulation of cadherin-based
adhesions. The endothelium also forms attachments with surrounding proteins and
cells via 2 classes of adhesion molecules, the integrins and IgCAMs. Integrins
and IgCAMs propagate activation of multiple downstream signals that potentially
impact cadherin adhesion. Here we discuss the known contributions of integrin and
IgCAM signaling to the regulation of cadherin adhesion stability, endothelial
barrier function, and vascular permeability. Emphasis is placed on known and
prospective crosstalk signaling mechanisms between integrins, the IgCAMs- ICAM-1
and PECAM-1, and inter-endothelial cadherin adhesions, as potential strategic
signaling nodes for multipartite regulation of cadherin adhesion.