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10.1007/s00018-016-2433-5 http://scihub22266oqcxt.onion/10.1007/s00018-016-2433-5 C5418326!5418326 !27999899     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27999899 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27999899 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Life+Sci 2017 ; 74 (11 ): 1937-1956 Nephropedia Template TP {{tp|p=27999899 |t=2017. Control of signaling molecule range during developmental patterning |pdf=|usr=}}{{27999899 }} gab.com Text Control of signaling molecule range during developmental patterning JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27999899 #FOAvip Tissue patterning, through the concerted activity of a small number of signaling pathways, is critical to embryonic development. While patterning can involve signaling between neighbouring cells, in other contexts signals act over greater distances by traversing complex cellular landscapes to instruct the fate of distant cells. In this review, we explore different strategies adopted by cells to modulate signaling molecule range to allow correct patterning. We describe mechanisms for restricting signaling range and highlight how such short-range signaling can be exploited to not only control the fate of adjacent cells, but also to generate graded signaling within a field of cells. Other strategies include modulation of signaling molecule action by tissue architectural properties and the use of cellular membranous structures, such as signaling filopodia and exosomes, to actively deliver signaling ligands to target cells. Signaling filopodia can also be deployed to reach out and collect particular signals, thereby precisely controlling their site of action. Twit Text FOAVip Control of signaling molecule range during developmental patterning ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27999899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27999899 #FOAvip English Wikipedia <ref>{{Cite pmid|27999899 }}</ref> Control of signaling molecule range during developmental patterning #MMPMID27999899 Wilcockson SG ; Sutcliffe C ; Ashe HL Cell Mol Life Sci 2017[Jun]; 74 (11 ): 1937-1956 PMID27999899 show ga Tissue patterning, through the concerted activity of a small number of signaling pathways, is critical to embryonic development. While patterning can involve signaling between neighbouring cells, in other contexts signals act over greater distances by traversing complex cellular landscapes to instruct the fate of distant cells. In this review, we explore different strategies adopted by cells to modulate signaling molecule range to allow correct patterning. We describe mechanisms for restricting signaling range and highlight how such short-range signaling can be exploited to not only control the fate of adjacent cells, but also to generate graded signaling within a field of cells. Other strategies include modulation of signaling molecule action by tissue architectural properties and the use of cellular membranous structures, such as signaling filopodia and exosomes, to actively deliver signaling ligands to target cells. Signaling filopodia can also be deployed to reach out and collect particular signals, thereby precisely controlling their site of action. |*Body Patterning [MESH] |*Embryonic Development [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Surface Extensions/metabolism [MESH] |Extracellular Vesicles/metabolism [MESH] |Humans [MESH]Control of signaling molecule range during developmental patterning (epmc).pdf DeepDyve Pubget Overpricing