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10.1098/rsif.2016.0848 http://scihub22266oqcxt.onion/10.1098/rsif.2016.0848 C5332569!5332569 !28202588     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28202588 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+R+Soc+Interface 2017 ; 14 (127 ): ä Nephropedia Template TP {{tp|p=28202588 |t=2017. Control and regulation of pathways via negative feedback |pdf=|usr=}}{{28202588 }} gab.com Text Control and regulation of pathways via negative feedback JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=28202588 #FOAvip The biochemical networks found in living organisms include a huge variety of control mechanisms at multiple levels of organization. While the mechanistic and molecular details of many of these control mechanisms are understood, their exact role in driving cellular behaviour is not. For example, yeast glycolysis has been studied for almost 80 years but it is only recently that we have come to understand the systemic role of the multitude of feedback and feed-forward controls that exist in this pathway. In this article, control theory is discussed as an approach to dissect the control logic of complex pathways. One of the key issues is distinguishing between the terms control and regulation and how these concepts are applied to regulated enzymes such as phosphofructokinase. In doing so, one of the paradoxes in metabolic regulation can be resolved where enzymes such as phosphofructokinase have little control but, nevertheless, possess significant regulatory influence. Twit Text FOAVip Control and regulation of pathways via negative feedback ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=28202588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28202588 #FOAvip English Wikipedia <ref>{{Cite pmid|28202588 }}</ref> Control and regulation of pathways via negative feedback #MMPMID28202588 Sauro HM J R Soc Interface 2017[Feb]; 14 (127 ): ä PMID28202588 show ga The biochemical networks found in living organisms include a huge variety of control mechanisms at multiple levels of organization. While the mechanistic and molecular details of many of these control mechanisms are understood, their exact role in driving cellular behaviour is not. For example, yeast glycolysis has been studied for almost 80 years but it is only recently that we have come to understand the systemic role of the multitude of feedback and feed-forward controls that exist in this pathway. In this article, control theory is discussed as an approach to dissect the control logic of complex pathways. One of the key issues is distinguishing between the terms control and regulation and how these concepts are applied to regulated enzymes such as phosphofructokinase. In doing so, one of the paradoxes in metabolic regulation can be resolved where enzymes such as phosphofructokinase have little control but, nevertheless, possess significant regulatory influence. |*Models, Biological [MESH] |Glycolysis/*physiology [MESH] |Phosphofructokinases/*metabolism [MESH] |Saccharomyces cerevisiae Proteins/*metabolism [MESH] |Saccharomyces cerevisiae/*physiology [MESH]Control and regulation of pathways via negative feedback (epmc).pdf DeepDyve Pubget Overpricing