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10.4161/21541264.2014.967602

http://scihub22266oqcxt.onion/10.4161/21541264.2014.967602
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suck abstract from ncbi


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pmid25483604
      Transcription 2014 ; 5 (4 ): e967602
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  • Contribution of transcription to animal early development #MMPMID25483604
  • Wang J ; Davis RE
  • Transcription 2014[]; 5 (4 ): e967602 PMID25483604 show ga
  • In mature gametes and during the oocyte-to-embryo transition, transcription is generally silenced and gene expression is post-transcriptionally regulated. However, we recently discovered that major transcription can occur immediately after fertilization, prior to pronuclear fusion, and in the first cell division of the oocyte-to-embryo transition in the nematode Ascaris suum. We postulate that the balance between transcriptional and post-transcriptional regulation during the oocyte-to-embryo transition may largely be determined by cell cycle length and thus the time available for the genome to be transcribed.
  • |*Transcription, Genetic [MESH]
  • |Animals [MESH]
  • |Ascaris/genetics/*growth & development/metabolism [MESH]
  • |Caenorhabditis elegans/genetics/growth & development/metabolism [MESH]
  • |Cell Cycle Checkpoints [MESH]
  • |Embryonic Development [MESH]
  • |Gene Expression Regulation, Developmental [MESH]
  • |Oocytes/growth & development/metabolism [MESH]
  • |Protein Processing, Post-Translational [MESH]
  • |RNA-Binding Proteins/genetics/metabolism [MESH]
  • |Xenopus/genetics/growth & development/metabolism [MESH]


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