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2014 ; 3
(3
): e970459
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Contribution of chaperones to STAT pathway signaling
#MMPMID26413421
Bocchini CE
; Kasembeli MM
; Roh SH
; Tweardy DJ
JAKSTAT
2014[]; 3
(3
): e970459
PMID26413421
show ga
Aberrant STAT signaling is associated with the development and progression of
many cancers and immune related diseases. Recent findings demonstrate that
proteostasis modulators under clinical investigation for cancer therapy have a
significant impact on STAT signaling, which may be critical for mediating their
anti-cancer effects. Chaperones are critical for protein folding, stability and
function and, thus, play an essential role in the maintenance of proteostasis. In
this review we discuss the role of chaperones in STAT and tyrosine kinase (TK)
protein folding, modulation of STAT and TK activity, and degradation of TKs. We
highlight the important role of chaperones in STAT signaling, and how this
knowledge has provided a framework for the development of new therapeutic avenues
of targeting STAT signaling related pathologies.
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