Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26445600
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26445600
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ther+Adv+Urol
2015 ; 7
(4
): 203-15
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Contemporary diagnosis and management of Fournier s gangrene
#MMPMID26445600
Chennamsetty A
; Khourdaji I
; Burks F
; Killinger KA
Ther Adv Urol
2015[Aug]; 7
(4
): 203-15
PMID26445600
show ga
Fournier's gangrene, an obliterative endarteritis of the subcutaneous arteries
resulting in gangrene of the overlying skin, is a rare but severe infective
necrotizing fasciitis of the external genitalia. Mainly associated with men and
those over the age of 50, Fournier's gangrene has been shown to have a
predilection for patients with diabetes as well as people who are long-term
alcohol misusers. The nidus for the synergistic polymicrobial infection is
usually located in the genitourinary tract, lower gastointestinal tract or skin.
Early diagnosis remains imperative as rapid progression of the gangrene can lead
to multiorgan failure and death. The diagnosis is often made clinically, although
radiography can be helpful when the diagnosis or the extent of the disease is
difficult to discern. The Laboratory Risk Indicator for Necrotizing Fasciitis
score can be used to stratify patients into low, moderate or high risk and the
Fournier's Gangrene Severity Index (FGSI) can also be used to determine the
severity and prognosis of Fournier's gangrene. Mainstays of treatment include
rapid and aggressive surgical debridement of necrotized tissue, hemodynamic
support with urgent resuscitation with fluids, and broad-spectrum parental
antibiotics. After initial radical debridement, open wounds are generally managed
with sterile dressings and negative-pressure wound therapy. In cases of severe
perineal involvement, colostomy has been used for fecal diversion or
alternatively, the Flexi-Seal Fecal Management System can be utilized to prevent
fecal contamination of the wound. After extensive debridement, many patients
sustain significant defects of the skin and soft tissue, creating a need for
reconstructive surgery for satisfactory functional and cosmetic results.