Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26357786
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Extra+Corpor+Technol
2014 ; 46
(3
): 212-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Contemporary Oxygenator Design Relative to Hemolysis
#MMPMID26357786
Venema LH
; Sharma AS
; Simons AP
; Bekers O
; Weerwind PW
J Extra Corpor Technol
2014[Sep]; 46
(3
): 212-6
PMID26357786
show ga
Hemolysis is a well-known phenomenon during cardiovascular surgery and generally
attributed to cardiopulmonary bypass, particularly when using high-resistant
oxygenators. This study aimed at investigating whether transoxygenator pressure
drop can be considered an independent factor of hemolysis. Additionally,
intraoxygenator blood distribution and shear stress were assessed. A
low-resistant (LR, n = 3), a moderate-resistant (MR, n = 3), and a high-resistant
(HR, n = 3) clinically used membrane oxygenator were tested in vitro using a
roller pump and freshly drawn heparinized porcine blood. Flow rates were set to 2
and 4 L/min and maximum flow compliant to the oxygenator type for 1 hour each. As
a control, the oxygenator was excluded from the system. Blood samples were taken
every 30 minutes for plasma-free hemoglobin assay and transoxygenator pressure
was measured inline. Intraoxygenator blood distribution was assessed using an
ultrasound dilution technique. Despite the relatively broad spectrum of pressure
drop and resultant transoxygenator pressure drops (LR: 14-41 mmHg, MR: 29-115
mmHg, HR: 77-284 mmHg, respectively), no significant association (R2 = .074, p =
.22) was found with the normalized index of hemolysis. The shear stress of each
oxygenator at maximum flow rate amounted to 3.0 N/m2 (LR), 5.7 N/m2 (MR), and 8.4
N/m2 (HR), respectively. Analysis of blood flow distribution curves (kurtosis and
skewness) revealed intraoxygenator blood flow distribution to become more
homogeneous when blood flow rates increased. Contemporary oxygenators were shown
not to be a predominant factor for red blood cell damage.