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10.1371/journal.pntd.0005093 http://scihub22266oqcxt.onion/10.1371/journal.pntd.0005093 C5091901!5091901 !27806049     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27806049 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27806049 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Negl+Trop+Dis 2016 ; 10 (11 ): e0005093 Nephropedia Template TP {{tp|p=27806049 |t=2016. Containing Ebola at the Source with Ring Vaccination |pdf=|usr=}}{{27806049 }} gab.com Text Containing Ebola at the Source with Ring Vaccination JO: PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=27806049 #FOAvip Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus disease outbreaks. To provide a numerical estimate of the effectiveness of ring vaccination strategies we introduce a spatially explicit agent-based model to simulate Ebola outbreaks in the Pujehun district, Sierra Leone, structurally similar to previous modelling approaches. We find that ring vaccination can successfully contain an outbreak for values of the effective reproduction number up to 1.6. Through an extensive sensitivity analysis of parameters characterising the readiness and capacity of the health care system, we identify interventions that, alongside ring vaccination, could increase the likelihood of containment. In particular, shortening the time from symptoms onset to hospitalisation to 2-3 days on average through improved contact tracing procedures, adding a 2km spatial component to the vaccination ring, and decreasing human mobility by quarantining affected areas might contribute increase our ability to contain outbreaks with effective reproduction number up to 2.6. These results have implications for future control of Ebola and other emerging infectious disease threats. Twit Text FOAVip Containing Ebola at the Source with Ring Vaccination ????PLoS Negl Trop Dis http://www.kidney.de/pget.php?&tw=1&pmid=27806049 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27806049 #FOAvip English Wikipedia <ref>{{Cite pmid|27806049 }}</ref> Containing Ebola at the Source with Ring Vaccination #MMPMID27806049 Merler S ; Ajelli M ; Fumanelli L ; Parlamento S ; Pastore Y Piontti A ; Dean NE ; Putoto G ; Carraro D ; Longini IM Jr ; Halloran ME ; Vespignani A PLoS Negl Trop Dis 2016[Nov]; 10 (11 ): e0005093 PMID27806049 show ga Interim results from the Guinea Ebola ring vaccination trial suggest high efficacy of the rVSV-ZEBOV vaccine. These findings open the door to the use of ring vaccination strategies in which the contacts and contacts of contacts of each index case are promptly vaccinated to contain future Ebola virus disease outbreaks. To provide a numerical estimate of the effectiveness of ring vaccination strategies we introduce a spatially explicit agent-based model to simulate Ebola outbreaks in the Pujehun district, Sierra Leone, structurally similar to previous modelling approaches. We find that ring vaccination can successfully contain an outbreak for values of the effective reproduction number up to 1.6. Through an extensive sensitivity analysis of parameters characterising the readiness and capacity of the health care system, we identify interventions that, alongside ring vaccination, could increase the likelihood of containment. In particular, shortening the time from symptoms onset to hospitalisation to 2-3 days on average through improved contact tracing procedures, adding a 2km spatial component to the vaccination ring, and decreasing human mobility by quarantining affected areas might contribute increase our ability to contain outbreaks with effective reproduction number up to 2.6. These results have implications for future control of Ebola and other emerging infectious disease threats. |Ebola Vaccines/*administration & dosage [MESH] |Ebolavirus/*physiology [MESH] |Guinea/epidemiology [MESH] |Hemorrhagic Fever, Ebola/epidemiology/*prevention & control [MESH] |Humans [MESH] |Models, Biological [MESH] |Sierra Leone/epidemiology [MESH]Containing Ebola at the Source with Ring Vaccination (epmc).pdf DeepDyve Pubget Overpricing