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2016 ; 51
(6
): 413-439
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Connexins and their channels in inflammation
#MMPMID27387655
Willebrords J
; Crespo Yanguas S
; Maes M
; Decrock E
; Wang N
; Leybaert L
; Kwak BR
; Green CR
; Cogliati B
; Vinken M
Crit Rev Biochem Mol Biol
2016[Nov]; 51
(6
): 413-439
PMID27387655
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Inflammation may be caused by a variety of factors and is a hallmark of a
plethora of acute and chronic diseases. The purpose of inflammation is to
eliminate the initial cell injury trigger, to clear out dead cells from damaged
tissue and to initiate tissue regeneration. Despite the wealth of knowledge
regarding the involvement of cellular communication in inflammation, studies on
the role of connexin-based channels in this process have only begun to emerge in
the last few years. In this paper, a state-of-the-art overview of the effects of
inflammation on connexin signaling is provided. Vice versa, the involvement of
connexins and their channels in inflammation will be discussed by relying on
studies that use a variety of experimental tools, such as genetically modified
animals, small interfering RNA and connexin-based channel blockers. A better
understanding of the importance of connexin signaling in inflammation may open up
towards clinical perspectives.