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10.3390/ijms19061663

http://scihub22266oqcxt.onion/10.3390/ijms19061663
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suck abstract from ncbi


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pmid29874791
      Int+J+Mol+Sci 2018 ; 19 (6 ): ä
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  • Connexins and Pannexins in Vascular Function and Disease #MMPMID29874791
  • Molica F ; Figueroa XF ; Kwak BR ; Isakson BE ; Gibbins JM
  • Int J Mol Sci 2018[Jun]; 19 (6 ): ä PMID29874791 show ga
  • Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes.
  • |Cardiovascular Physiological Phenomena/*genetics [MESH]
  • |Connexins/*genetics/metabolism [MESH]
  • |Coronary Vessels/metabolism/*physiology [MESH]
  • |Gap Junctions/genetics [MESH]
  • |Homeostasis [MESH]
  • |Humans [MESH]
  • |Ion Channels/*genetics [MESH]
  • |Membrane Proteins/genetics [MESH]


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