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2017 ; 7
(1
): 9720
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Connecting individual to collective cell migration
#MMPMID28852093
George M
; Bullo F
; Campās O
Sci Rep
2017[Aug]; 7
(1
): 9720
PMID28852093
show ga
Collective cell migration plays a pivotal role in the formation of organs, tissue
regeneration, wound healing and many disease processes, including cancer. Despite
the considerable existing knowledge on the molecular control of cell movements,
it is unclear how the different observed modes of collective migration,
especially for small groups of cells, emerge from the known behaviors of
individual cells. Here we derive a physical description of collective cellular
movements from first principles, while accounting for known phenomenological cell
behaviors, such as contact inhibition of locomotion and force-induced cell
repolarization. We show that this theoretical description successfully describes
the motion of groups of cells of arbitrary numbers, connecting single cell
behaviors and parameters (e.g., adhesion and traction forces) to the collective
migration of small groups of cells and the expansion of large cell colonies.
Specifically, using a common framework, we explain how cells characterized by
contact inhibition of locomotion can display coherent collective behavior when in
groups, even in the absence of biochemical signaling. We find an optimal group
size leading to maximal group persistence and show that cell proliferation
prevents the buildup of intercellular forces within cell colonies, enabling their
expansion.
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