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2018 ; 7
(2
): 105-118
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Confocal Microscopy in Skin Cancer
#MMPMID29780659
Ahlgrimm-Siess V
; Laimer M
; Rabinovitz HS
; Oliviero M
; Hofmann-Wellenhof R
; Marghoob AA
; Scope A
Curr Dermatol Rep
2018[]; 7
(2
): 105-118
PMID29780659
show ga
PURPOSE OF REVIEW: Reflectance confocal microscopy (RCM) enables imaging of skin
lesions at cellular level resolution at the bedside (in vivo) or in freshly
excised tissue (ex vivo). This article provides an overview of strengths and
limitations of non-invasive RCM in skin cancer diagnosis. RECENT FINDINGS: RCM
features of common melanocytic and non-melanocytic skin neoplasms such as
melanoma, actinic keratosis/squamous cell carcinoma, basal cell carcinoma, and
nevi have been well defined and show good correlation with dermoscopic and
histopathologic findings. Due to its technical properties, RCM is especially
suitable for the examination of flat skin lesions. SUMMARY: In vivo RCM has been
shown to increase the accuracy of non-invasive diagnosis of common skin neoplasms
and is a valuable adjunct to dermoscopy, particularly in cosmetically and
functionally sensitive areas such as the face or the genital area.