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2010 ; 11
(12
): 1691-702
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Conference scene: pediatric pharmacogenomics and personalized medicine
#MMPMID21142913
Leeder JS
; Lantos J
; Spielberg SP
Pharmacogenomics
2010[Dec]; 11
(12
): 1691-702
PMID21142913
show ga
A major challenge for clinicians, pharmaceutical companies and regulatory
agencies is to better understand the relative contributions of ontogeny and
genetic variation to observed variability in drug disposition and response across
the pediatric age spectrum from preterm and term newborns, to infants, children
and adolescents. Extrapolation of adult experience with pharmacogenomics and
personalized medicine to pediatric patients of different ages and developmental
stages, is fraught with many challenges. Compared with adults, pediatric
pharmacogenetics and pharmacogenomics involves an added measure of complexity as
variability owing to developmental processes, or ontogeny, is superimposed upon
genetic variation. Furthermore, some pediatric diseases have no adult correlate
or are more prevalent in children compared with adults, and several adverse drug
reactions are unique to children, or occur at a higher frequency in children. The
primary objective of this conference was to initiate an ongoing series of annual
meetings on ?Pediatric Pharmacogenomics and Personalized Medicine? organized by
the Center for Personalized Medicine and Therapeutic Innovation and Division of
Clinical Pharmacology and Medical Therapeutics at Children?s Mercy Hospitals and
Clinics in Kansas City, MO, USA. The primary goals of the inaugural meeting were:
to bring together clinicians, basic and translational scientists and allied
healthcare practitioners, and engage in a multi- and cross-disciplinary dialog
aimed at implementing personalized medicine in pediatric settings; to provide a
forum for the presentation and the dissemination of research related to the
application of pharmacogenomic strategies to investigations of variability of
drug disposition and response in children; to explore the ethical, legal and
societal implications of pharmacogenomics and personalized medicine that are
unique to children; and finally, to create networking opportunities for
stimulating discussion, cooperation and collaboration to devise strategies to
address the research needs identified.
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