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10.1038/ncomms6998

http://scihub22266oqcxt.onion/10.1038/ncomms6998
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C4454288!4454288 !25601659
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suck abstract from ncbi

pmid25601659
      Nat+Commun 2015 ; 6 (?): 5998
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  • Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids #MMPMID25601659
  • Kurczy ME ; Zhu ZJ ; Ivanisevic J ; Schuyler AM ; Lalwani K ; Santidrian AF ; David JM ; Giddabasappa A ; Roberts AJ ; Olivos HJ ; O'Brien PJ ; Franco L ; Fields MW ; Paris LP ; Friedlander M ; Johnson CH ; Epstein AA ; Gendelman HE ; Wood MR ; Felding BH ; Patti GJ ; Spilker ME ; Siuzdak G
  • Nat Commun 2015[Jan]; 6 (?): 5998 PMID25601659 show ga
  • Fluorocarbons are lipophobic and non-polar molecules that exhibit remarkable biocompatibility, with applications in liquid ventilation and synthetic blood. The unique properties of these compounds have also enabled mass spectrometry imaging of tissues where the fluorocarbons act as a Teflon-like coating for nanostructured surfaces to assist in desorption/ionization. Here we report fluorinated gold nanoparticles (f-AuNPs) designed to facilitate nanostructure imaging mass spectrometry. Irradiation of f-AuNPs results in the release of the fluorocarbon ligands providing a driving force for analyte desorption. The f-AuNPs allow for the mass spectrometry analysis of both lipophilic and polar (central carbon) metabolites. An important property of AuNPs is that they also act as contrast agents for X-ray microtomography and electron microscopy, a feature we have exploited by infusing f-AuNPs into tissue via fluorocarbon liquids to facilitate multimodal (molecular and anatomical) imaging.
  • |Diagnostic Imaging/*methods [MESH]
  • |Gold/*chemistry [MESH]
  • |Mass Spectrometry [MESH]
  • |Metal Nanoparticles/*chemistry [MESH]
  • |Microscopy, Electron [MESH]


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