Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28249159
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Rep
2017 ; 18
(9
): 2124-2134
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Composition and Function of Mutant Swi/Snf Complexes
#MMPMID28249159
Dutta A
; Sardiu M
; Gogol M
; Gilmore J
; Zhang D
; Florens L
; Abmayr SM
; Washburn MP
; Workman JL
Cell Rep
2017[Feb]; 18
(9
): 2124-2134
PMID28249159
show ga
The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to
humans. It functions to alter nucleosome positions by either sliding nucleosomes
on DNA or evicting histones. Interestingly, 20% of all human cancers carry
mutations in subunits of the Swi/Snf complex. Many of these mutations cause
protein instability and loss, resulting in partial Swi/Snf complexes. Although
several studies have shown that histone acetylation and activator-dependent
recruitment of Swi/Snf regulate its function, it is less well understood how
subunits regulate stability and function of the complex. Using functional
proteomic and genomic approaches, we have assembled the network architecture of
yeast Swi/Snf. In addition, we find that subunits of the Swi/Snf complex regulate
occupancy of the catalytic subunit Snf2, thereby modulating gene transcription.
Our findings have direct bearing on how cancer-causing mutations in orthologous
subunits of human Swi/Snf may lead to aberrant regulation of gene expression by
this complex.
|Adenosine Triphosphatases/genetics
[MESH]
|Catalysis
[MESH]
|Chromatin Assembly and Disassembly/*genetics
[MESH]
free
free
free
