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10.1038/srep46395 http://scihub22266oqcxt.onion/10.1038/srep46395 C5404331!5404331 !28440326     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28440326 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28440326 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 46395 Nephropedia Template TP {{tp|p=28440326 |t=2017. Complex multifractal nature in Mycobacterium tuberculosis genome |pdf=|usr=}}{{28440326 }} gab.com Text Complex multifractal nature in Mycobacterium tuberculosis genome JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28440326 #FOAvip The mutifractal and long range correlation (C(r)) properties of strings, such as nucleotide sequence can be a useful parameter for identification of underlying patterns and variations. In this study C(r) and multifractal singularity function f(?) have been used to study variations in the genomes of a pathogenic bacteria Mycobacterium tuberculosis. Genomic sequences of M. tuberculosis isolates displayed significant variations in C(r) and f(?) reflecting inherent differences in sequences among isolates. M. tuberculosis isolates can be categorised into different subgroups based on sensitivity to drugs, these are DS (drug sensitive isolates), MDR (multi-drug resistant isolates) and XDR (extremely drug resistant isolates). C(r) follows significantly different scaling rules in different subgroups of isolates, but all the isolates follow one parameter scaling law. The richness in complexity of each subgroup can be quantified by the measures of multifractal parameters displaying a pattern in which XDR isolates have highest value and lowest for drug sensitive isolates. Therefore C(r) and multifractal functions can be useful parameters for analysis of genomic sequences. Twit Text FOAVip Complex multifractal nature in Mycobacterium tuberculosis genome ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28440326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28440326 #FOAvip English Wikipedia <ref>{{Cite pmid|28440326 }}</ref> Complex multifractal nature in Mycobacterium tuberculosis genome #MMPMID28440326 Mandal S ; Roychowdhury T ; Chirom K ; Bhattacharya A ; Brojen Singh RK Sci Rep 2017[Apr]; 7 (ä): 46395 PMID28440326 show ga The mutifractal and long range correlation (C(r)) properties of strings, such as nucleotide sequence can be a useful parameter for identification of underlying patterns and variations. In this study C(r) and multifractal singularity function f(?) have been used to study variations in the genomes of a pathogenic bacteria Mycobacterium tuberculosis. Genomic sequences of M. tuberculosis isolates displayed significant variations in C(r) and f(?) reflecting inherent differences in sequences among isolates. M. tuberculosis isolates can be categorised into different subgroups based on sensitivity to drugs, these are DS (drug sensitive isolates), MDR (multi-drug resistant isolates) and XDR (extremely drug resistant isolates). C(r) follows significantly different scaling rules in different subgroups of isolates, but all the isolates follow one parameter scaling law. The richness in complexity of each subgroup can be quantified by the measures of multifractal parameters displaying a pattern in which XDR isolates have highest value and lowest for drug sensitive isolates. Therefore C(r) and multifractal functions can be useful parameters for analysis of genomic sequences. |*Genetic Variation [MESH] |*Genome, Bacterial [MESH] |Drug Resistance, Multiple, Bacterial/genetics [MESH] |Microbial Sensitivity Tests [MESH]Complex multifractal nature in Mycobacterium tuberculosis genome (epmc).pdf DeepDyve Pubget Overpricing