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10.1016/j.blre.2017.02.003 http://scihub22266oqcxt.onion/10.1016/j.blre.2017.02.003 C5513767!5513767 !28215731     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28215731 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28215731 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood+Rev 2017 ; 31 (4 ): 213-223 Nephropedia Template TP {{tp|p=28215731 |t=2017. Complementopathies |pdf=|usr=}}{{28215731 }} gab.com Text Complementopathies JO: Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=28215731 #FOAvip The complement system is an essential part of the innate immune system that requires careful regulation to ensure responses are appropriately directed against harmful pathogens, while preventing collateral damage to normal host cells and tissues. While deficiency in some components of the complement pathway is associated with increased susceptibility to certain infections, it has also become clear that inappropriate activation of complement is an important contributor to human disease. A number of hematologic disorders are driven by complement, and these disorders may be termed "complementopathies". This includes paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), cold agglutinin disease (CAD) and other related disorders, which will be the focus of this review. A better understanding of the central role of the complement system in the pathophysiology of these disorders may allow for application of therapies directed at blocking the complement cascade. Twit Text FOAVip Complementopathies ????Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=28215731 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28215731 #FOAvip English Wikipedia <ref>{{Cite pmid|28215731 }}</ref> Complementopathies #MMPMID28215731 Baines AC ; Brodsky RA Blood Rev 2017[Jul]; 31 (4 ): 213-223 PMID28215731 show ga The complement system is an essential part of the innate immune system that requires careful regulation to ensure responses are appropriately directed against harmful pathogens, while preventing collateral damage to normal host cells and tissues. While deficiency in some components of the complement pathway is associated with increased susceptibility to certain infections, it has also become clear that inappropriate activation of complement is an important contributor to human disease. A number of hematologic disorders are driven by complement, and these disorders may be termed "complementopathies". This includes paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), cold agglutinin disease (CAD) and other related disorders, which will be the focus of this review. A better understanding of the central role of the complement system in the pathophysiology of these disorders may allow for application of therapies directed at blocking the complement cascade. |*Complement Activation [MESH] |Adaptive Immunity [MESH] |Anemia, Hemolytic, Autoimmune/*immunology/pathology/therapy [MESH] |Animals [MESH] |Atypical Hemolytic Uremic Syndrome/*immunology/pathology/therapy [MESH] |Complement System Proteins/*immunology [MESH] |Female [MESH] |HELLP Syndrome/*immunology/pathology/therapy [MESH] |Hemoglobinuria, Paroxysmal/*immunology/pathology/therapy [MESH] |Humans [MESH] |Immunity, Innate [MESH]Complementopathies (epmc).pdf DeepDyve Pubget Overpricing