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10.1038/nrneph.2016.70 http://scihub22266oqcxt.onion/10.1038/nrneph.2016.70 C4974115!4974115 !27211870     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27211870 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Nephrol 2016 ; 12 (7 ): 383-401 Nephropedia Template TP {{tp|p=27211870 |t=2016. Complement in disease: a defence system turning offensive |pdf=|usr=}}{{27211870 }} gab.com Text Complement in disease: a defence system turning offensive JO: Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27211870 #FOAvip Although the complement system is primarily perceived as a host defence system, a more versatile, yet potentially more harmful side of this innate immune pathway as an inflammatory mediator also exists. The activities that define the ability of the complement system to control microbial threats and eliminate cellular debris - such as sensing molecular danger patterns, generating immediate effectors, and extensively coordinating with other defence pathways - can quickly turn complement from a defence system to an aggressor that drives immune and inflammatory diseases. These host-offensive actions become more pronounced with age and are exacerbated by a variety of genetic factors and autoimmune responses. Complement can also be activated inappropriately, for example in response to biomaterials or transplants. A wealth of research over the past two decades has led to an increasingly finely tuned understanding of complement activation, identified tipping points between physiological and pathological behaviour, and revealed avenues for therapeutic intervention. This Review summarizes our current view of the key activating, regulatory, and effector mechanisms of the complement system, highlighting important crosstalk connections, and, with an emphasis on kidney disease and transplantation, discusses the involvement of complement in clinical conditions and promising therapeutic approaches. Twit Text FOAVip Complement in disease: a defence system turning offensive ????Nat Rev Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=27211870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27211870 #FOAvip English Wikipedia <ref>{{Cite pmid|27211870 }}</ref> Complement in disease: a defence system turning offensive #MMPMID27211870 Ricklin D ; Reis ES ; Lambris JD Nat Rev Nephrol 2016[Jul]; 12 (7 ): 383-401 PMID27211870 show ga Although the complement system is primarily perceived as a host defence system, a more versatile, yet potentially more harmful side of this innate immune pathway as an inflammatory mediator also exists. The activities that define the ability of the complement system to control microbial threats and eliminate cellular debris - such as sensing molecular danger patterns, generating immediate effectors, and extensively coordinating with other defence pathways - can quickly turn complement from a defence system to an aggressor that drives immune and inflammatory diseases. These host-offensive actions become more pronounced with age and are exacerbated by a variety of genetic factors and autoimmune responses. Complement can also be activated inappropriately, for example in response to biomaterials or transplants. A wealth of research over the past two decades has led to an increasingly finely tuned understanding of complement activation, identified tipping points between physiological and pathological behaviour, and revealed avenues for therapeutic intervention. This Review summarizes our current view of the key activating, regulatory, and effector mechanisms of the complement system, highlighting important crosstalk connections, and, with an emphasis on kidney disease and transplantation, discusses the involvement of complement in clinical conditions and promising therapeutic approaches. |Animals [MESH] |Atypical Hemolytic Uremic Syndrome/immunology [MESH] |Complement System Proteins/*physiology [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Immune System/physiology [MESH] |Immunotherapy [MESH] |Kidney Diseases/*immunology [MESH] |Signal Transduction [MESH]Complement in disease: a defence system turning offensive (epmc).pdf DeepDyve Pubget Overpricing