Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28611987
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28611987
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Med+(Lausanne)
2017 ; 4
(ä): 66
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Complement in Kidney Transplantation
#MMPMID28611987
Cernoch M
; Viklicky O
Front Med (Lausanne)
2017[]; 4
(ä): 66
PMID28611987
show ga
The complement system is considered to be an important part of innate immune
system with a significant role in inflammation processes. The activation can
occur through classical, alternative, or lectin pathway, resulting in the
creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune
functions, and the assembly of terminal complement cascade, capable of direct
cell lysis. The activation processes are tightly regulated; inappropriate
activation of the complement cascade plays a significant role in many renal
diseases including organ transplantation. Moreover, complement cascade is
activated during ischemia/reperfusion injury processes and influences delayed
graft function of kidney allografts. Interestingly, complement system has been
found to play a role in both acute cellular and antibody-mediated rejections and
thrombotic microangiopathy. Therefore, complement system may represent an
interesting therapeutical target in kidney transplant pathologies.