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10.1016/j.ekir.2017.10.005 http://scihub22266oqcxt.onion/10.1016/j.ekir.2017.10.005 C5932121!5932121 !29725633     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29725633 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int+Rep 2018 ; 3 (2 ): 302-313 Nephropedia Template TP {{tp|p=29725633 |t=2018. Complement Activation in Patients With Diabetic Nephropathy |pdf=|usr=}}{{29725633 }} gab.com Text Complement Activation in Patients With Diabetic Nephropathy JO: Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29725633 #FOAvip INTRODUCTION: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. METHODS: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease. The presence of complement deposits was scored by researchers who were blinded with respect to the clinical and histological data. RESULTS: C4d deposits were more prevalent in cases with DN than in cases without DN in both the glomeruli (46% vs. 26%) and the arterioles (28% vs. 12%). C1q deposits were also increased in the glomerular hili (77% vs. 55%) and arterioles (33% vs.14%), and were correlated with DN (P < 0.01). MBL deposits were only rarely observed. C5b-9 deposits were more prevalent in the cases with diabetes mellitus (DM) than in the cases without DM (69% vs. 32%; P < 0.001). Finally, glomerular C4d and C5b-9 deposits were correlated with the severity of DN (? = 0.341 and 0.259, respectively; P < 0.001). CONCLUSION: Complement activation is correlated with both the presence and severity of DN, suggesting that the complement system is involved in the development of renal pathology in patients with diabetes and is a promising target for inhibiting and/or preventing DN in these patients. Twit Text FOAVip Complement Activation in Patients With Diabetic Nephropathy ????Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29725633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29725633 #FOAvip English Wikipedia <ref>{{Cite pmid|29725633 }}</ref> Complement Activation in Patients With Diabetic Nephropathy #MMPMID29725633 Bus P ; Chua JS ; Klessens CQF ; Zandbergen M ; Wolterbeek R ; van Kooten C ; Trouw LA ; Bruijn JA ; Baelde HJ Kidney Int Rep 2018[Mar]; 3 (2 ): 302-313 PMID29725633 show ga INTRODUCTION: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. METHODS: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease. The presence of complement deposits was scored by researchers who were blinded with respect to the clinical and histological data. RESULTS: C4d deposits were more prevalent in cases with DN than in cases without DN in both the glomeruli (46% vs. 26%) and the arterioles (28% vs. 12%). C1q deposits were also increased in the glomerular hili (77% vs. 55%) and arterioles (33% vs.14%), and were correlated with DN (P < 0.01). MBL deposits were only rarely observed. C5b-9 deposits were more prevalent in the cases with diabetes mellitus (DM) than in the cases without DM (69% vs. 32%; P < 0.001). Finally, glomerular C4d and C5b-9 deposits were correlated with the severity of DN (? = 0.341 and 0.259, respectively; P < 0.001). CONCLUSION: Complement activation is correlated with both the presence and severity of DN, suggesting that the complement system is involved in the development of renal pathology in patients with diabetes and is a promising target for inhibiting and/or preventing DN in these patients. äComplement Activation in Patients With Diabetic Nephropathy (epmc).pdf DeepDyve Pubget Overpricing