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2018 ; 3
(ä): 6
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Comparative regenerative mechanisms across different mammalian tissues
#MMPMID29507774
Iismaa SE
; Kaidonis X
; Nicks AM
; Bogush N
; Kikuchi K
; Naqvi N
; Harvey RP
; Husain A
; Graham RM
NPJ Regen Med
2018[]; 3
(ä): 6
PMID29507774
show ga
Stimulating regeneration of complex tissues and organs after injury to effect
complete structural and functional repair, is an attractive therapeutic option
that would revolutionize clinical medicine. Compared to many metazoan phyla that
show extraordinary regenerative capacity, which in some instances persists
throughout life, regeneration in mammalians, particularly humans, is limited or
absent. Here we consider recent insights in the elucidation of molecular
mechanisms of regeneration that have come from studies of tissue homeostasis and
injury repair in mammalian tissues that span the spectrum from little or no
self-renewal, to those showing active cell turnover throughout life. These
studies highlight the diversity of factors that constrain regeneration, including
immune responses, extracellular matrix composition, age, injury type,
physiological adaptation, and angiogenic and neurogenic capacity. Despite these
constraints, much progress has been made in elucidating key molecular mechanisms
that may provide therapeutic targets for the development of future regenerative
therapies, as well as previously unidentified developmental paradigms and
windows-of-opportunity for improved regenerative repair.