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2017 ; 6
(1
): 1-11
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Comparative genomics of human stem cell factor (SCF)
#MMPMID28447043
Dehbashi M
; Kamali E
; Vallian S
Mol Biol Res Commun
2017[Mar]; 6
(1
): 1-11
PMID28447043
show ga
Stem cell factor (SCF) is a critical protein with key roles in the cell such as
hematopoiesis, gametogenesis and melanogenesis. In the present study a
comparative analysis on nucleotide sequences of SCF was performed in Humanoids
using bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse. Our analysis
of nucleotide sequences to find closely evolved organisms with high similarity by
NCBI-BLAST tools and MEGA6 showed that human and Chimpanzee (Pan troglodytes)
were placed into the same cluster. By using JBrowse, we found that SCF in
Neanderthal had a single copy number similar to modern human and partly conserved
nucleotide sequences. Together, the results approved the gene flow and genetics
similarity of SCF among human and P. troglodytes. This may suggest that during
evolution, SCF gene transferred partly intact either on the basis of sequence or
function from the same ancestors to P. troglodytes, the ancient human like
Neanderthal, and then to the modern human.