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Commentary: the year in circadian rhythms
#MMPMID20926591
Sassone-Corsi P
Mol Endocrinol
2010[Nov]; 24
(11
): 2081-7
PMID20926591
show ga
The circadian clock orchestrates intrinsic timing in most organisms and controls
a large variety of physiological and metabolic programs. In my presentation "The
Year in Circadian Rhythms" at the Endocrine Society meeting (San Diego, June
2010) I reviewed some of the recent spectacular developments of the field. The
exceptional interest that circadian rhythms have suscitated during the past two
decades has caused a remarkable increase in the number of researchers and of
committed resources dedicated to the field. This has also generated the promise
of potentially novel pharmacological strategies. Indeed, specific molecular
pathways of circadian regulation have been recently linked to endocrine and
metabolic control, as well as cell cycle and proliferation. Importantly,
circadian gene expression involves an important proportion of cellular genes,
underscoring the role played by dynamic mechanisms of chromatin remodeling. This
suggests that the circadian machinery could have evolved as a privileged
molecular interface between cellular metabolism and epigenetic control.
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