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2015 ; 16
(8
): 17952-74
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Combined Screening for Early Detection of Pre-Eclampsia
#MMPMID26247944
Park HJ
; Shim SS
; Cha DH
Int J Mol Sci
2015[Aug]; 16
(8
): 17952-74
PMID26247944
show ga
Although the precise pathophysiology of pre-eclampsia remains unknown, this
condition continues to be a major cause of maternal and fetal mortality. Early
prediction of pre-eclampsia would allow for timely initiation of preventive
therapy. A combination of biophysical and biochemical markers are superior to
other tests for early prediction of the development of pre-eclampsia. Apart from
the use of parameters in first-trimester aneuploidy screening, cell-free fetal
DNA quantification is emerging as a promising marker for prediction of
pre-eclampsia. This article reviews the current research of the most important
strategies for prediction of pre-eclampsia, including the use of maternal risk
factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.