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2017 ; 8
(2
): 169-185
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Combinatorial strategies for combating invasive fungal infections
#MMPMID27268286
Spitzer M
; Robbins N
; Wright GD
Virulence
2017[Feb]; 8
(2
): 169-185
PMID27268286
show ga
Invasive fungal infections are an important cause of human mortality and
morbidity, particularly for immunocompromised populations. However, there remains
a paucity of antifungal drug treatments available to combat these fungal
pathogens. Further, antifungal compounds are plagued with problems such as host
toxicity, fungistatic activity, and the emergence of drug resistance in pathogen
populations. A promising therapeutic strategy to increase drug effectiveness and
mitigate the emergence of drug resistance is through the use of combination drug
therapy. In this review we describe the current arsenal of antifungals in
medicine and elaborate on the benefits of combination therapy to expand our
current antifungal drug repertoire. We examine those antifungal combinations that
have shown potential against fungal pathogens and discuss strategies being
employed to discover novel combination therapeutics, in particular combining
antifungal agents with non-antifungal bioactive compounds. The findings
summarized in this review highlight the promise of combinatorial strategies in
combatting invasive mycoses.
|*Drug Synergism
[MESH]
|Animals
[MESH]
|Antifungal Agents/adverse effects/pharmacology/*therapeutic use
[MESH]
free
free
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