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10.21037/atm.2016.01.31 http://scihub22266oqcxt.onion/10.21037/atm.2016.01.31 C4791344!4791344 !27047959     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27047959 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Transl+Med 2016 ; 4 (5 ): 100 Nephropedia Template TP {{tp|p=27047959 |t=2016. Combination therapy for metastatic renal cell carcinoma |pdf=|usr=}}{{27047959 }} gab.com Text Combination therapy for metastatic renal cell carcinoma JO: Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=27047959 #FOAvip Current therapy for metastatic clear cell renal cell carcinoma (RCC) consists of the serial administration of single agents. Combinations of VEGF and mTOR inhibitors have been disappointing in previous randomized trials. However, the combination of lenvatinib, a multitargeted agent that inhibits VEGF as well as FGF receptors, and everolimus demonstrated promising results in a randomized phase II trial. Moreover, the emergence of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors has spawned the investigation of combinations of these agents with VEGF inhibitors and cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors. These ongoing phase III trials in conjunction with the development of predictive biomarkers and agents inhibiting novel therapeutic targets may provide much needed advances in this still largely incurable disease. Twit Text FOAVip Combination therapy for metastatic renal cell carcinoma ????Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=27047959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27047959 #FOAvip English Wikipedia <ref>{{Cite pmid|27047959 }}</ref> Combination therapy for metastatic renal cell carcinoma #MMPMID27047959 Buonerba C ; Di Lorenzo G ; Sonpavde G Ann Transl Med 2016[Mar]; 4 (5 ): 100 PMID27047959 show ga Current therapy for metastatic clear cell renal cell carcinoma (RCC) consists of the serial administration of single agents. Combinations of VEGF and mTOR inhibitors have been disappointing in previous randomized trials. However, the combination of lenvatinib, a multitargeted agent that inhibits VEGF as well as FGF receptors, and everolimus demonstrated promising results in a randomized phase II trial. Moreover, the emergence of programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors has spawned the investigation of combinations of these agents with VEGF inhibitors and cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitors. These ongoing phase III trials in conjunction with the development of predictive biomarkers and agents inhibiting novel therapeutic targets may provide much needed advances in this still largely incurable disease. äCombination therapy for metastatic renal cell carcinoma (epmc).pdf DeepDyve Pubget Overpricing