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2017 ; 9
(6
): 451-456
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Combination Antifungal Therapy: A Review of Current Data
#MMPMID28496543
Campitelli M
; Zeineddine N
; Samaha G
; Maslak S
J Clin Med Res
2017[Jun]; 9
(6
): 451-456
PMID28496543
show ga
The incidence of invasive fungal infections has been on the rise, particularly in
transplant recipients and in patients with hematological malignancies and other
forms of immunosuppression. There is a mismatch between the rate of antifungal
resistance and the development of new antifungal agents. Based on this, the idea
of combining antifungals in the treatment of invasive fungal infections appears
tempting for many clinicians, particularly after many in vitro studies showed
synergism between many antifungal agents. Several randomized controlled trials
have been published regarding the efficacy and safety of combination of
antifungals, but the high cost, the limited number of cases and the multitude of
confounding factors lead in some instances to weak and sometimes contradictory
results. The lack of consensus in many clinical scenarios raises the importance
of the need for more studies about combination antifungal therapies and should
incite infectious disease societies to develop specific recommendations for the
clinicians to follow while approaching patients with invasive fungal infections.