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10.1038/nrdp.2015.65 http://scihub22266oqcxt.onion/10.1038/nrdp.2015.65 C4874655!4874655 !27189416     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27189416 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Dis+Primers 2015 ; 1 (ä): 15065 Nephropedia Template TP {{tp|p=27189416 |t=2015. Colorectal cancer |pdf=|usr=}}{{27189416 }} gab.com Text Colorectal cancer JO: Nat Rev Dis Primers http://www.kidney.de/pget.php?&tw=1&pmid=27189416 #FOAvip Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment. Twit Text FOAVip Colorectal cancer ????Nat Rev Dis Primers http://www.kidney.de/pget.php?&tw=1&pmid=27189416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27189416 #FOAvip English Wikipedia <ref>{{Cite pmid|27189416 }}</ref> Colorectal cancer #MMPMID27189416 Kuipers EJ ; Grady WM ; Lieberman D ; Seufferlein T ; Sung JJ ; Boelens PG ; van de Velde CJ ; Watanabe T Nat Rev Dis Primers 2015[Nov]; 1 (ä): 15065 PMID27189416 show ga Colorectal cancer had a low incidence several decades ago. However, it has become a predominant cancer and now accounts for approximately 10% of cancer-related mortality in western countries. The 'rise' of colorectal cancer in developed countries can be attributed to the increasingly ageing population, unfavourable modern dietary habits and an increase in risk factors, such as smoking, low physical exercise and obesity. New treatments for primary and metastatic colorectal cancer have emerged, providing additional options for patients; these treatments include laparoscopic surgery for primary disease, more-aggressive resection of metastatic disease (such as liver and pulmonary metastases), radiotherapy for rectal cancer, and neoadjuvant and palliative chemotherapies. However, these new treatment options have had limited impact on cure rates and long-term survival. For these reasons, and the recognition that colorectal cancer is long preceded by a polypoid precursor, screening programmes have gained momentum. This Primer provides an overview of the current state of the art of knowledge on the epidemiology and mechanisms of colorectal cancer, as well as on diagnosis and treatment. |*Colorectal Neoplasms/epidemiology/etiology/therapy [MESH] |Antineoplastic Combined Chemotherapy Protocols/therapeutic use [MESH] |Colectomy/trends [MESH] |Colonic Polyps/complications [MESH] |Humans [MESH] |Incidence [MESH] |Laparoscopy/methods/trends [MESH] |Radiotherapy/trends [MESH]Colorectal cancer (epmc).pdf DeepDyve Pubget Overpricing