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10.1038/nchembio.1754 http://scihub22266oqcxt.onion/10.1038/nchembio.1754 C4806783!4806783 !25689336     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25689336 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem+Biol 2015 ; 11 (3 ): 182-8 Nephropedia Template TP {{tp|p=25689336 |t=2015. Collective antibiotic tolerance: mechanisms, dynamics and intervention |pdf=|usr=}}{{25689336 }} gab.com Text Collective antibiotic tolerance: mechanisms, dynamics and intervention JO: Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25689336 #FOAvip Bacteria have developed resistance against every antibiotic at a rate that is alarming considering the timescale at which new antibiotics are developed. Thus, there is a critical need to use antibiotics more effectively, extend the shelf life of existing antibiotics and minimize their side effects. This requires understanding the mechanisms underlying bacterial drug responses. Past studies have focused on survival in the presence of antibiotics by individual cells, as genetic mutants or persisters. Also important, however, is the fact that a population of bacterial cells can collectively survive antibiotic treatments lethal to individual cells. This tolerance can arise by diverse mechanisms, including resistance-conferring enzyme production, titration-mediated bistable growth inhibition, swarming and interpopulation interactions. These strategies can enable rapid population recovery after antibiotic treatment and provide a time window during which otherwise susceptible bacteria can acquire inheritable genetic resistance. Here, we emphasize the potential for targeting collective antibiotic tolerance behaviors as an antibacterial treatment strategy. Twit Text FOAVip Collective antibiotic tolerance: mechanisms, dynamics and intervention ????Nat Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25689336 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25689336 #FOAvip English Wikipedia <ref>{{Cite pmid|25689336 }}</ref> Collective antibiotic tolerance: mechanisms, dynamics and intervention #MMPMID25689336 Meredith HR ; Srimani JK ; Lee AJ ; Lopatkin AJ ; You L Nat Chem Biol 2015[Mar]; 11 (3 ): 182-8 PMID25689336 show ga Bacteria have developed resistance against every antibiotic at a rate that is alarming considering the timescale at which new antibiotics are developed. Thus, there is a critical need to use antibiotics more effectively, extend the shelf life of existing antibiotics and minimize their side effects. This requires understanding the mechanisms underlying bacterial drug responses. Past studies have focused on survival in the presence of antibiotics by individual cells, as genetic mutants or persisters. Also important, however, is the fact that a population of bacterial cells can collectively survive antibiotic treatments lethal to individual cells. This tolerance can arise by diverse mechanisms, including resistance-conferring enzyme production, titration-mediated bistable growth inhibition, swarming and interpopulation interactions. These strategies can enable rapid population recovery after antibiotic treatment and provide a time window during which otherwise susceptible bacteria can acquire inheritable genetic resistance. Here, we emphasize the potential for targeting collective antibiotic tolerance behaviors as an antibacterial treatment strategy. |Animals [MESH] |Anti-Bacterial Agents/*pharmacology/therapeutic use [MESH] |Bacteria/drug effects [MESH] |Bacterial Infections/drug therapy/microbiology [MESH] |Drug Resistance, Bacterial/drug effects/*physiology [MESH]Collective antibiotic tolerance: mechanisms, dynamics and intervention(epmc).pdf DeepDyve Pubget Overpricing