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10.1080/15476286.2015.1034923

http://scihub22266oqcxt.onion/10.1080/15476286.2015.1034923
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suck abstract from ncbi


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pmid25970135
      RNA+Biol 2015 ; 12 (6 ): 590-6
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  • Coilin: The first 25 years #MMPMID25970135
  • Machyna M ; Neugebauer KM ; Stan?k D
  • RNA Biol 2015[]; 12 (6 ): 590-6 PMID25970135 show ga
  • Initially identified as a marker of coiled bodies (now Cajal bodies or CBs), the protein coilin was discovered a quarter of century ago. Coilin is now known to scaffold the CB, but its structure and function are poorly understood. Nearly devoid of predicted structural motifs, coilin has numerous reported molecular interactions that must underlie its role in the formation and function of CBs. In this review, we summarize what we have learned in the past 25 years about coilin's structure, post-transcriptional modifications, and interactions with RNA and proteins. We show that genes with homology to human coilin are found in primitive metazoans and comment on differences among model organisms. Coilin's function in Cajal body formation and RNP metabolism will be discussed in the light of these developments.
  • |*Protein Processing, Post-Translational [MESH]
  • |Animals [MESH]
  • |Coiled Bodies/*metabolism [MESH]
  • |History, 20th Century [MESH]
  • |History, 21st Century [MESH]
  • |Humans [MESH]


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