Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25970135
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25970135
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 RNA+Biol
2015 ; 12
(6
): 590-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Coilin: The first 25 years
#MMPMID25970135
Machyna M
; Neugebauer KM
; Stan?k D
RNA Biol
2015[]; 12
(6
): 590-6
PMID25970135
show ga
Initially identified as a marker of coiled bodies (now Cajal bodies or CBs), the
protein coilin was discovered a quarter of century ago. Coilin is now known to
scaffold the CB, but its structure and function are poorly understood. Nearly
devoid of predicted structural motifs, coilin has numerous reported molecular
interactions that must underlie its role in the formation and function of CBs. In
this review, we summarize what we have learned in the past 25 years about
coilin's structure, post-transcriptional modifications, and interactions with RNA
and proteins. We show that genes with homology to human coilin are found in
primitive metazoans and comment on differences among model organisms. Coilin's
function in Cajal body formation and RNP metabolism will be discussed in the
light of these developments.